HAEM-LOKᵀᴹ Collection Tube for Cell-Free DNA
The HAEM-LOKᵀᴹ collection tube for blood uses a novel approach to the collection of cell-free plasma DNA. Using a combination of a barrier matrix, a special barrier fluid and a single centrifugation step, all blood cells are relocated below a physical barrier shortly after collection, producing cell-free plasma. No harsh chemicals such as cell fixatives or precipitants are employed. Removing all cells early prevents the later release of cellular DNA from lysed cells, a common cause of failure of other collection tubes. After initial centrifugation, blood samples in HAEM-LOKᵀᴹ can be kept in the original tube at ambient temperature for 2 - 3 weeks, simplifying shipment and scheduling.
HAEM-Lok™ was developed at deltaDNA Biosciences and initially validated by measuring cell-free fetal DNA in blood samples taken from >200 women at different stages of pregnancy. Its major application is expected to be cell-free tumor (ct) DNA.